The comprehensive on-demand 3D bio-printing for composite reconstruction of mandibular defects
박한익, 이지호, 이상진,
소속 상세정보
박한익 ( Park Han-Ick ) - University of Ulsan College of Medicine Asan Medical Center Department of Oral and Maxillofacial Surgery
이지호 ( Lee Jee-Ho ) - University of Ulsan College of Medicine Asan Medical Center Department of Oral and Maxillofacial Surgery
이상진 ( Lee Sang-Jin ) - Wake Forest School of Medicine Wake Forest Institute for Regenerative Medicine
Abstract
Background: The mandible is a functional bio-organ that supports facial structures and helps mastication and speaking. Large mandible defects, generally greater than 6-cm segment loss, may require composite tissue reconstruction such as osteocutaneous-vascularized free flap which has a limitation of additional surgery and a functional morbidity at the donor site. A 3D bio-printing technology is recently developed to overcome the limitation in the composite reconstruction of the mandible using osteocutaneous-vascularized free flap.
Review: Scaffold, cells, and bioactive molecules are essential for a 3D bio-printing. For mandibular reconstruction, materials in a 3D bio-printing require mechanical strength, resilience, and biocompatibility. Recently, an integrated tissue and organ printing system with multiple cartridges are designed and it is capable of printing polymers to reinforce the printed structure, such as hydrogel.
Conclusion: For successful composite tissue reconstruction of the mandible, biologic considerations and components should be presented with a comprehensive on-demand online platform model of customized approaches.
키워드
Mandibular defect; Reconstruction of the mandible; Osteocutaneous-vascularized free flap; 3D bio-printing technology; Integrated tissue; Organ printing
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